Morbidity and mortality in young-onset type 2 diabetes in comparison to type 1 diabetes: where are we now?

Curr Diab Rep. 2015 Jan;15(1):566. doi: 10.1007/s11892-014-0566-1.


Increasingly, we recognise that type 2 diabetes in youth is a disease with an aggressive time course and a significant complication risk. On the other hand, outcomes for youth with type 1 diabetes appear generally to be improving. With increasing numbers of both types of diabetes in youth, it is timely that a comparative perspective is offered to help clinicians prognosticate more appropriately. Contemporary comparative studies add a new perspective to a consistent story, that for youth-onset type 2 diabetes, the development and progression of cardio-renal complications are increased and the survival prognosis is significantly worse than for type 1 diabetes. Here, we review this mounting evidence, highlight the importance of metabolic syndrome factors in the excess risk and underscore that there remains a significant mortality gap for youth with either type of diabetes, to be addressed as a matter of urgency.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Adolescent
  • Age of Onset
  • Albuminuria / etiology
  • Albuminuria / mortality*
  • Cardiovascular Diseases / mortality
  • Child
  • Diabetes Complications / mortality*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / mortality*
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / mortality*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetic Angiopathies / mortality
  • Diabetic Nephropathies / mortality
  • Diabetic Neuropathies / mortality
  • Disease Progression
  • Humans
  • Risk Factors