Successful delivery of RRT in Ebola virus disease

J Am Soc Nephrol. 2015 Jan;26(1):31-7. doi: 10.1681/ASN.2014111057. Epub 2014 Nov 14.


AKI has been observed in cases of Ebola virus disease. We describe the protocol for the first known successful delivery of RRT with subsequent renal recovery in a patient with Ebola virus disease treated at Emory University Hospital, in Atlanta, Georgia. Providing RRT in Ebola virus disease is complex and requires meticulous attention to safety for the patient, healthcare workers, and the community. We specifically describe measures to decrease the risk of transmission of Ebola virus disease and report pilot data demonstrating no detectable Ebola virus genetic material in the spent RRT effluent waste. This article also proposes clinical practice guidelines for acute RRT in Ebola virus disease.

Keywords: AKI; Ebola virus disease; biocontainment isolation; continuous RRT.

MeSH terms

  • Acute Kidney Injury / complications
  • Acute Kidney Injury / therapy*
  • Communicable Disease Control / methods*
  • Health Personnel
  • Hemorrhagic Fever, Ebola / complications
  • Hemorrhagic Fever, Ebola / therapy*
  • Humans
  • Occupational Exposure
  • Patient Isolation / methods*
  • Patient Safety
  • Pilot Projects
  • Practice Guidelines as Topic
  • Real-Time Polymerase Chain Reaction
  • Renal Replacement Therapy / methods*
  • Treatment Outcome