¹⁸F-fluorodeoxyglucose PET/CT features and correlations with histopathologic characteristics in sclerosing epithelioid fibrosarcoma

Int J Clin Exp Pathol. 2014 Sep 15;7(10):7278-85. eCollection 2014.

Abstract

Sclerosing epithelioid fibrosarcoma (SEF) is a clinicopathologically distinct variant of fibrosarcoma that is capable of recurrence and metastasis. Awareness of imaging features and histopathologic characteristics will be helpful for differential diagnosis from other common tumors. Here, we report a case of SEF metastasizing to the pancreas as a solitary mass mimicking primary pancreatic cancer, and summarize the reported cases with FDG PET/CT from the literature (n=4). PET/CT showed abnormal FDG accumulation (n=2), mild FDG uptake (n=1), or photopenic (n=1). The FDG PET/CT features are closely related to histopathologic characteristics regarding its differentiation and aggressiveness.

Keywords: FDG; PET/CT; Sclerosing epitheloid fibrosarcoma; pancreas.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biopsy
  • Diagnosis, Differential
  • Epithelioid Cells* / diagnostic imaging
  • Epithelioid Cells* / pathology
  • Fibrosarcoma / diagnosis*
  • Fibrosarcoma / diagnostic imaging
  • Fibrosarcoma / secondary
  • Fibrosarcoma / surgery
  • Fluorodeoxyglucose F18*
  • Humans
  • Immunohistochemistry
  • Male
  • Multimodal Imaging
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / diagnostic imaging
  • Pancreatic Neoplasms / secondary
  • Pancreatic Neoplasms / surgery
  • Pancreaticoduodenectomy
  • Positron-Emission Tomography*
  • Predictive Value of Tests
  • Radiopharmaceuticals*
  • Sclerosis
  • Tomography, X-Ray Computed*
  • Treatment Outcome

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18