Epistasis analysis using ReliefF

Methods Mol Biol. 2015:1253:315-25. doi: 10.1007/978-1-4939-2155-3_17.


Here we introduce the ReliefF machine learning algorithm and some of its extensions for detecting and characterizing epistasis in genetic association studies. We provide a general overview of the method and then highlight some of the modifications that have greatly improved its power for genetic analysis. We end with a few examples of published studies of complex human diseases that have used ReliefF.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms*
  • Epistasis, Genetic*
  • Humans
  • Tuberculosis, Pulmonary / genetics
  • Urinary Bladder Neoplasms / genetics