The relationship between lifetime suicide attempts, serum lipid levels, and metabolic syndrome in patients with bipolar disorders

Int J Psychiatry Clin Pract. 2015 Jun;19(2):124-31. doi: 10.3109/13651501.2014.988271. Epub 2014 Dec 16.


Objectives: To assess the relationship between lifetime suicide attempts (SAs), serum lipid values, and metabolic syndrome (MetS) in patients with bipolar disorders (BPD).

Methods: Eighty patients with BPD took part in the study (M = 40.60 years). After psychiatric diagnosis, demographic data, SAs, and serum lipids were measured and MetS was calculated.

Results: 70% reported at least one suicide attempt. 52.5% suffered from MetS. Suicide attempters had higher cholesterol values. SAs were associated with a family history of suicide, current mood state, and lower educational level. SAs were unrelated to MetS.

Conclusions: In patients with BPD, against expectations, the occurrence of SAs was associated with higher cholesterol values. Serum lipid values are not suitable as a biological trait marker to predict SAs.

Keywords: Lifetime suicide attempts; bipolar disorder; metabolic syndrome; serum lipid profiles.

MeSH terms

  • Adult
  • Bipolar Disorder / blood*
  • Bipolar Disorder / epidemiology
  • Cholesterol / blood*
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / epidemiology
  • Middle Aged
  • Suicide, Attempted / statistics & numerical data*


  • Cholesterol