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. 2014 Nov 19;14:1185.
doi: 10.1186/1471-2458-14-1185.

Prevalence and Risk Factors for Cervical Neoplasia: A Cervical Cancer Screening Program in Beijing

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Free PMC article

Prevalence and Risk Factors for Cervical Neoplasia: A Cervical Cancer Screening Program in Beijing

Lixin Tao et al. BMC Public Health. .
Free PMC article

Abstract

Background: Cervical cancer is the second most common cancer and cause of cancer-related death for women worldwide. The aims of this study were to investigate the prevalence of cervical neoplasia and examine factors associated with high-grade cervical squamous intraepithelial lesions (HSIL) among women taking part in a cervical cancer screening program in Beijing.

Methods: Women aged 25-65 years were screened using the ThinPrep cytologic test and gynecologic examination. Univariate and multivariate logistic regressions were conducted to investigate factors associated with HSIL.

Results: Among 728,704 women screened, the prevalence of cervical intraepithelial neoplasia (CIN) I, II, III was 50.2, 34.0, and 36.4 per 100,000, respectively. Prevalence of cervical cancer was 12.2 per 100,000. Risk factors for HSIL included being in age group of 46-55 years (adjusted odds ratio [aOR] = 1.15, 95% CI: 1.07-1.44, compared with the 25-35 age group), bleeding after intercourse (aOR = 2.08, 95% CI: 1.40-3.10), and presence of trichomonas vaginalis infection (aOR = 2.62, 95% CI: 1.35-5.07), cervical inflammation (aOR = 4.22, 95% CI: 3.39-5.26), and genital warts (aOR = 3.89, 95% CI: 2.54-7.70). High education level (college and above compared with junior middle school or lower) was found to be protective (aOR = 0.79, 95% CI: 0.37-0.90).

Conclusions: The prevalence of cervical neoplasia is relatively high in Beijing. Women aged 46-55 years, those with a lower education level, those reporting bleeding after intercourse, and those affected by Trichomonas vaginalis infection, cervical inflammation and genital warts are at higher risk for HSIL. Particular efforts should be made to ensure these women are included in cervical cancer screening programs.

Figures

Figure 1
Figure 1
The prevalence of a) HSIL and b) cervical cancer in 18 districts of Beijing. Abbreviation: HSIL = high-grade squamous intraepithelial lesion.
Figure 2
Figure 2
Adjusted OR and 95% CI for risk factors for HSIL. Abbreviation: HSIL = high-grade squamous intraepithelial lesion; age group (46–55 vs 25–35); education level (college and above vs junior middle school or lower).

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References

    1. Bekkers RL, Massuger LF, Bulten J, Melchers WJ. Epidemiological and clinical aspects of human papillomavirus detection in the prevention of cervical cancer. Rev Med Virol. 2004;14(2):95–105. doi: 10.1002/rmv.416. - DOI - PubMed
    1. Chirenje ZM. HIV and cancer of the cervix. Best Pract Res Clin Obstet Gynaecol. 2005;19(2):269–276. doi: 10.1016/j.bpobgyn.2004.10.002. - DOI - PubMed
    1. Wu MT, Lee LH, Ho CK, Wu SC, Lin LY, Cheng BH, Liu CL, Yang CY, Tsai HT, Wu TN. Environmental exposure to cooking oil fumes and cervical intraepithelial neoplasm. Environ Res. 2004;94(1):25–32. doi: 10.1016/S0013-9351(03)00118-X. - DOI - PubMed
    1. Verhoef VM, Heideman DA, van Kemenade FJ, Rozendaal L, Bosgraaf RP, Hesselink AT, Bekkers RL, Massuger LF, Steenbergen RD, Snijders PJ, Berkhof J, Meijer CJ. Methylation marker analysis and HPV16/18 genotyping in high-risk HPV positive self-sampled specimens to identify women with high grade CIN or cervical cancer. Gynecol oncol. 2014;135(1):58–63. doi: 10.1016/j.ygyno.2014.08.003. - DOI - PubMed
    1. Agorastos T, Chatzistamatiou K, Zafrakas M, Siamanta V, Katsamagkas T, Constantinidis TC, Lampropoulos AF, Lysistrata study group Epidemiology of HPV infection and current status of cervical cancer prevention in Greece: final results of the LYSISTRATA cross-sectional study. Eur J cancer prev. 2014;23(5):425–431. doi: 10.1097/CEJ.0000000000000060. - DOI - PubMed
Pre-publication history
    1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/14/1185/prepub
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