Global displacement of canine parvovirus by a host-adapted variant: structural comparison between pandemic viruses with distinct host ranges

J Virol. 2015 Feb;89(3):1909-12. doi: 10.1128/JVI.02611-14. Epub 2014 Nov 19.


Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Capsid Proteins / chemistry
  • Crystallography, X-Ray
  • Dog Diseases / epidemiology
  • Dog Diseases / virology*
  • Dogs
  • Host Specificity*
  • Models, Molecular
  • Mutant Proteins / chemistry
  • Pandemics
  • Parvoviridae Infections / epidemiology
  • Parvoviridae Infections / veterinary*
  • Parvoviridae Infections / virology
  • Parvovirus, Canine / chemistry
  • Parvovirus, Canine / isolation & purification
  • Parvovirus, Canine / physiology*
  • Protein Conformation


  • Capsid Proteins
  • Mutant Proteins

Associated data

  • PDB/4QYK