Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 37 (12), 841-50

Polycomb-mediated Gene Silencing in Arabidopsis Thaliana

Affiliations
Review

Polycomb-mediated Gene Silencing in Arabidopsis Thaliana

Dong-Hwan Kim et al. Mol Cells.

Abstract

Polycomb group (PcG) proteins are conserved chromatin regulators involved in the control of key developmental programs in eukaryotes. They collectively provide the transcriptional memory unique to each cell identity by maintaining transcriptional states of developmental genes. PcG proteins form multi-protein complexes, known as Polycomb repressive complex 1 (PRC1) and Polycomb repressive complex 2 (PRC2). PRC1 and PRC2 contribute to the stable gene silencing in part through catalyzing covalent histone modifications. Components of PRC1 and PRC2 are well conserved from plants to animals. PcG-mediated gene silencing has been extensively investigated in efforts to understand molecular mechanisms underlying developmental programs in eukaryotes. Here, we describe our current knowledge on PcG-mediated gene repression which dictates developmental programs by dynamic layers of regulatory activities, with an emphasis given to the model plant Arabidopsis thaliana.

Keywords: chromatin looping; epigenetics; gene silencing; polycomb; trithorax.

Figures

Fig. 1
Fig. 1
Conserved components of PRC1 and PRC2 between Drosophila and Arabidopsis. Core components of Drosophila PRC2 and PRC1 (upper) and the homologous subunits found in Arabidopsis (bottom) were presented. Functional equivalents of PcG complex are indicated with the same color. EMF1 and VRN1 are plant-specific proteins in Arabidopsis PRC1-like complex.
Fig. 2
Fig. 2
Several proposed modes of the recruitment of PcG and TrxG complexes. (A) PcG complexes, PRC1 or PRC2 physically interacts with transcription factors (TFs) or lncRNAs to be recruited to specific target loci, containing PRE. Recruited PRC1 and PRC2 catalyze H2Aub1 (red circle) and H3K27me3 (green triangle) on target loci, respectively. Some TFs (i.e. AG) competes PRC2 out of target loci in a time-dependent manner. (B) TrxG complex is recruited to target loci through the interaction with TFs or lncRNAs. Recruited TrxG complex catalyze H3K4me3 (blue triangle) or H3K36me3 (purple pentagon) which inhibit PRC2 activity. TrxG-recruiting lncRNAs or DNA elements have not been identified in Arabidopsis.

Similar articles

See all similar articles

Cited by 5 PubMed Central articles

References

    1. Akasaka T., Kanno M., Balling R., Mieza M.A., Taniguchi M., Koseki H. A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Development. 1996;122:1513–1522. - PubMed
    1. Bantignies F., Cavalli G. Polycomb group proteins: repression in 3D. Trends Genet. 2011;27:454–464. - PubMed
    1. Bardos J.I., Saurin A.J., Tissot C., Duprez E., Freemont P.S. HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties. J. Biol. Chem. 2000;275:28785–28792. - PubMed
    1. Barrero J.M., Gonzalez-Bayon R., del Pozo J.C., Ponce M.R., Micol J.L. INCURVATA2 encodes the catalytic subunit of DNA Polymerase alpha and interacts with genes involved in chromatin-mediated cellular memory in Arabidopsis thaliana. Plant Cell. 2007;19:2822–2838. - PMC - PubMed
    1. Bastow R., Mylne J.S., Lister C., Lippman Z., Martienssen R.A., Dean C. Vernalization requires epigenetic silencing of FLC by histone methylation. Nature. 2004;427:164–167. - PubMed

Publication types

MeSH terms

Feedback