Pearly penile papules are frequently occurring lesions located over the corona and sulcus of the penis. They are asymptomatic and are considered to be acral angiofibromas. Some individuals, disturbed by their presence, request removal of the lesions. Even after patients are assured of the benign nature of the process and its relatively high incidence, prominent lesional involvement may still cause significant psychological distress. Two patients with pearly penile papules have been successfully treated with the carbon dioxide laser. A review of the literature and description of treated cases are presented.