Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition

Cell Res. 2014 Dec;24(12):1490-2. doi: 10.1038/cr.2014.153. Epub 2014 Nov 21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemistry
  • Adenosine / metabolism
  • Amino Acid Sequence
  • Crystallography, X-Ray
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • RNA-Binding Proteins / chemistry*
  • RNA-Binding Proteins / metabolism*
  • Sequence Alignment

Substances

  • RNA-Binding Proteins
  • YTHDF2 protein, human
  • N6-methyladenosine (m6A)
  • Adenosine

Associated data

  • PDB/4RDN
  • PDB/4RDO