An autosomal transcript in skeletal muscle with homology to dystrophin

Nature. 1989 May 4;339(6219):55-8. doi: 10.1038/339055a0.


The Duchenne muscular dystrophy (DMD) gene has been localized to chromosome Xp21 and codes for a 14-kilobase (kb) transcript and a protein called dystrophin, of relative molecular mass 427,000. Dystrophin is associated with the cytoplasmic face of muscle fibre membranes and its C-terminal domain is thought to mediate membrane attachment. Although N-terminal and central domain structures share common features with other cytoskeletal components, no significant sequence similarity between the C-terminal region of dystrophin and other previously characterized proteins has been described. Here we report that fragments from the C-terminal domain of the DMD complementary DNA detect a closely related sequence which exhibits nucleic-acid and predicted amino-acid identities with dystrophin of approximately 65 and 80%, respectively. The dystrophin-related sequence identifies a 13-kb transcript in human fetal muscle and maps to chromosome 6. Thus, dystrophin may be a member of a family of functionally related large structural proteins in muscle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cells, Cultured
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6
  • DNA / genetics
  • DNA Restriction Enzymes
  • Deoxyribonuclease EcoRI
  • Deoxyribonuclease HindIII
  • Dystrophin
  • Humans
  • Molecular Sequence Data
  • Muscle Proteins / genetics*
  • Muscles / analysis*
  • Muscles / embryology
  • Nucleic Acid Hybridization
  • RNA, Messenger / genetics
  • RNA, Messenger / isolation & purification
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic*


  • Dystrophin
  • Muscle Proteins
  • RNA, Messenger
  • DNA
  • DNA Restriction Enzymes
  • Deoxyribonuclease EcoRI
  • Deoxyribonuclease HindIII