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Review
. 2014 Dec 15;210 Suppl 3(Suppl 3):S616-21.
doi: 10.1093/infdis/jiu459.

Vaginal Microbiota and Sexually Transmitted Infections That May Influence Transmission of Cell-Associated HIV

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Free PMC article
Review

Vaginal Microbiota and Sexually Transmitted Infections That May Influence Transmission of Cell-Associated HIV

Richard A Cone. J Infect Dis. .
Free PMC article

Abstract

Vaginal microbiota and sexually transmitted infections (STIs) are likely to influence the transmission of cell-associated human immunodeficiency virus (HIV). Lactic acid produced by Lactobacillus-dominated microbiota (Nugent score 0-3) will likely inhibit transmission, especially female-to-male transmission. In contrast, polymicrobial microbiota (Nugent score 4-10), community state types IV-A and IV-B, and STIs will likely increase transmission of cell-associated HIV.

Keywords: cell-associated HIV; inflammatory cytokines; lactic acid; polymicrobial microbiota.

Figures

Figure 1.
Figure 1.
High prevalence of polymicrobial microbiota (intermediate and bacterial vaginosis [BV]; Nugent [morphotype] scores 4–6 and 7–10, respectively), and lower prevalence of normal Lactobacillus-dominated microbiota (Nugent score 0–3) [54, 55]. Abbreviations: US, United States; Rakai, Uganda.

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