Polyphosphate: a target for thrombosis attenuation

Blood. 2014 Nov 20;124(22):3177-8. doi: 10.1182/blood-2014-09-601641.

Abstract

In this issue of Blood, Travers et al report that a number of synthetic polyphosphate (polyP) inhibitors are able to reduce thrombosis in mice without increasing bleeding as much as heparin.

Publication types

  • Comment

MeSH terms

  • Animals
  • Dendrimers / pharmacology*
  • Fibrinolytic Agents / pharmacology*
  • Hemostasis / drug effects*
  • Humans
  • Polyphosphates / antagonists & inhibitors*
  • Thrombosis / prevention & control*

Substances

  • Dendrimers
  • Fibrinolytic Agents
  • Polyphosphates
  • UHRA-10
  • UHRA-9