Proton therapy in the management of lymphoma

Cancer J. 2014 Nov-Dec;20(6):387-92. doi: 10.1097/PPO.0000000000000076.


Hodgkin lymphoma and non-Hodgkin lymphoma are common hematologic malignancies with such a favorable prognosis that many survivors live decades after combined chemotherapy and radiotherapy. These survivors, however, are at risk of developing late treatment adverse effects from collateral damage, including secondary malignancies, cardiac toxicities, and ischemic heart diseases. Recent efforts have successfully reduced the radiation dose and treatment field without compromising cure rates. Proton therapy has the potential of further lowering the treatment-related toxicity owing to its ability to deposit a high dose only at the target. Although this finding has been supported by several current dosimetric studies, its utilization in the management of lymphoma has been limited during the past 5 years because of the paucity of facilities and the difficulty of obtaining insurance coverage. With diligent follow-up, the clinical impact of proton therapy will be established to improve the therapeutic ratio and to reduce late treatment-related morbidity.

Publication types

  • Review

MeSH terms

  • Cardiotoxicity / etiology
  • Cardiotoxicity / mortality
  • Cardiotoxicity / prevention & control
  • Hodgkin Disease / radiotherapy*
  • Humans
  • Lymphoma / radiotherapy*
  • Lymphoma, Non-Hodgkin / radiotherapy*
  • Neoplasms, Radiation-Induced / etiology
  • Neoplasms, Radiation-Induced / prevention & control
  • Neoplasms, Second Primary / etiology
  • Neoplasms, Second Primary / prevention & control
  • Proton Therapy* / adverse effects
  • Proton Therapy* / methods
  • Radiation Dosage