Genetic variation meets replication origins

Cell. 2014 Nov 20;159(5):973-974. doi: 10.1016/j.cell.2014.11.009.


Genome replication programs are highly orchestrated. In this issue, Koren and colleagues leverage whole-genome sequencing data to discover that DNA replication timing patterns differ between individuals and are associated with genetic variants. These so-called rtQTLs represent a new form of quantitative trait loci that may influence gene dosage and mutational frequency and provide mechanistic insights into the regulation of DNA replication.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Humans
  • Polymorphism, Genetic*
  • Quantitative Trait Loci*