Building robust transcriptomes with master splicing factors

Cell. 2014 Oct 23;159(3):487-98. doi: 10.1016/j.cell.2014.09.054.


Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Feedback
  • Gene Expression Regulation, Developmental*
  • Homeostasis
  • Humans
  • Organ Specificity
  • RNA Splicing*
  • RNA-Binding Proteins / metabolism*
  • Transcription Factors / metabolism
  • Transcriptome


  • RNA-Binding Proteins
  • Transcription Factors