SnapShot: the germinal center reaction

Cell. 2014 Oct 23;159(3):700-700.e1. doi: 10.1016/j.cell.2014.10.012.


To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.

MeSH terms

  • Animals
  • Antibodies / immunology*
  • Antigens / immunology
  • B-Lymphocytes / immunology
  • Germinal Center / metabolism*
  • T-Lymphocytes / immunology


  • Antibodies
  • Antigens