A CRISPR design for next-generation antimicrobials

Genome Biol. 2014 Nov 8;15(11):516. doi: 10.1186/s13059-014-0516-x.

Abstract

Two recent publications have demonstrated how delivering CRISPR nucleases provides a promising solution to the growing problem of bacterial antibiotic resistance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Animals
  • Anti-Infective Agents / administration & dosage*
  • CRISPR-Cas Systems*
  • Drug Resistance, Microbial / genetics*
  • Enterohemorrhagic Escherichia coli / genetics*
  • Gene Targeting*
  • RNA, Guide / genetics*
  • Ribonucleases / genetics*

Substances

  • Anti-Infective Agents
  • RNA, Guide
  • Ribonucleases