We are reporting a rare case of secretory breast cancer with axillary node involvement in a 16-year-old patient. Symptomatic systemic spread occured unusually early during adjuvant chemotherapy, suggesting primary resistance of the tumour to chemotherapy. We are unaware of any such case reports published world wide. Due to the small number of similar case reports in the literature, the natural history of this type of cancer remains uncertain, offering no development of firm treatment guidelines.