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, 6 (11), 4760-99

Nomenclature- And Database-Compatible Names for the Two Ebola Virus Variants That Emerged in Guinea and the Democratic Republic of the Congo in 2014

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Nomenclature- And Database-Compatible Names for the Two Ebola Virus Variants That Emerged in Guinea and the Democratic Republic of the Congo in 2014

Jens H Kuhn et al. Viruses.

Abstract

In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa. Epidemiological and evolutionary analyses confirmed that all cases of both outbreaks are connected to a single introduction each of EBOV into human populations and that both outbreaks are not directly connected. Coding-complete genomic sequence analyses of isolates revealed that the two outbreaks were caused by two novel EBOV variants, and initial clinical observations suggest that neither of them should be considered strains. Here we present consensus decisions on naming for both variants (West Africa: "Makona", Middle Africa: "Lomela") and provide database-compatible full, shortened, and abbreviated names that are in line with recently established filovirus sub-species nomenclatures.

Figures

Figure 1
Figure 1
Location of the Makona River.
Figure 2
Figure 2
Location of the Lomela River.

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References

    1. Baize S., Pannetier D., Oestereich L., Rieger T., Koivogui L., Magassouba N., Soropogui B., Sow M.S., Keita S., De Clerck H., et al. Emergence of Zaire Ebola virus disease in Guinea. N. Engl. J. Med. 2014;371:1418–1425. - PubMed
    1. Kuhn J.H., Becker S., Ebihara H., Geisbert T.W., Jahrling P.B., Kawaoka Y., Netesov S.V., Nichol S.T., Peters C.J., Volchkov V.E., et al. Family Filoviridae. In: King A.M.Q., Adams M.J., Carstens E.B., Lefkowitz E.J., editors. Virus Taxonomy—Ninth Report of the International Committee on Taxonomy of Viruses. Elsevier/Academic Press; London, UK: 2011. pp. 665–671.
    1. Calvignac-Spencer S., Schulze J.M., Zickmann F., Renard B.Y. Clock Rooting Further Demonstrates that Guinea 2014 EBOV is a Member of the Zaire Lineage. PLoS Curr. 2014;6 doi: 10.1371/currents.outbreaks.c0e035c86d721668a6ad7353f7f6fe86. - DOI - PMC - PubMed
    1. Dudas G., Rambaut A. Phylogenetic Analysis of Guinea 2014 EBOV Ebolavirus Outbreak. PLoS Curr. 2014;6 doi: 10.1371/currents.outbreaks.84eefe5ce43ec9dc0bf0670f7b8b417d. - DOI - PMC - PubMed
    1. World Health Organization Global Alert and Response (GAR) Situation Reports: Ebola Response Roadmap. World Health Organization; Geneva, Switzerland: 2014. [(accessed on 23 November 2014)]. Available online: http://apps.who.int/iris/bitstream/10665/136508/1/roadmapsitrep15Oct2014.pdf?ua=1.

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