Inhibition of c-Kit by tyrosine kinase inhibitors

Haematologica. 2015 Mar;100(3):e77-9. doi: 10.3324/haematol.2014.117028. Epub 2014 Nov 25.
No abstract available

Keywords: c-Kit inhibition; hair depigmentation; myelosuppression; tyrosine kinase inhibitors.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aminopyridines / therapeutic use
  • Antineoplastic Agents / therapeutic use*
  • Benzothiazoles / therapeutic use
  • Biomarkers / analysis
  • Bone Marrow / drug effects
  • Bone Marrow / enzymology
  • Bone Marrow / pathology
  • Cell Line, Tumor
  • Clinical Trials as Topic
  • Dasatinib
  • Gene Expression
  • Hair / drug effects
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / enzymology
  • Hematopoietic Stem Cells / pathology
  • Humans
  • Indazoles
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / enzymology
  • Leukemia, Myeloid, Acute / pathology
  • Niacinamide / analogs & derivatives
  • Niacinamide / therapeutic use
  • Phenylurea Compounds / therapeutic use
  • Pigmentation / drug effects
  • Protein Kinase Inhibitors / therapeutic use*
  • Proto-Oncogene Proteins c-kit / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-kit / genetics
  • Proto-Oncogene Proteins c-kit / metabolism
  • Pyrimidines / therapeutic use
  • Pyrroles / therapeutic use
  • Sorafenib
  • Sulfonamides / therapeutic use
  • Thiazoles / therapeutic use
  • fms-Like Tyrosine Kinase 3 / antagonists & inhibitors*
  • fms-Like Tyrosine Kinase 3 / genetics
  • fms-Like Tyrosine Kinase 3 / metabolism

Substances

  • Aminopyridines
  • Antineoplastic Agents
  • Benzothiazoles
  • Biomarkers
  • Indazoles
  • Phenylurea Compounds
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Pyrroles
  • Sulfonamides
  • Thiazoles
  • Niacinamide
  • pexidartinib
  • quizartinib
  • pazopanib
  • Sorafenib
  • FLT3 protein, human
  • Proto-Oncogene Proteins c-kit
  • fms-Like Tyrosine Kinase 3
  • Dasatinib