Anti-NMDA encephalitis: an uncommon, autoimmune mediated form of encephalitis

J Radiol Case Rep. 2014 Aug 31;8(8):1-6. doi: 10.3941/jrcr.v8i8.1566. eCollection 2014 Aug.

Abstract

We report an interesting case of a 19 year old female with findings on MRI suggestive of viral encephalitis. An extensive workup was negative for infectious causes and she was subsequently diagnosed with anti-NMDA encephalitis. Anti-NMDA encephalitis is a highly lethal but treatable form of autoimmune encephalitis that has recently been characterized. It is frequently found in young women and associated with an underlying teratoma. Although rare, this diagnosis should be considered in young females for whom a rapid onset of encephalitis cannot be explained by more common causes.

Keywords: Anti-NMDA; MRI; NMDA receptor; encephalitis; teratoma.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / cerebrospinal fluid
  • Autoimmune Diseases of the Nervous System / diagnosis*
  • Autoimmune Diseases of the Nervous System / drug therapy
  • Autoimmune Diseases of the Nervous System / immunology
  • Diagnosis, Differential
  • Encephalitis / diagnosis*
  • Encephalitis / drug therapy
  • Encephalitis / immunology*
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Magnetic Resonance Imaging
  • N-Methylaspartate / immunology*
  • Young Adult

Substances

  • Autoantibodies
  • Immunoglobulins, Intravenous
  • N-Methylaspartate