Association study of the SLITRK5 gene and Tourette syndrome

Psychiatr Genet. 2015 Feb;25(1):31-4. doi: 10.1097/YPG.0000000000000067.

Abstract

Tourette syndrome (TS) and obsessive-compulsive disorder commonly occur together. Family studies indicate shared genetic risk factors. SLITRK5, one of a family of six SLITRK genes, has been suggested as a possible candidate gene contributing towards obsessive-compulsive disorder on the basis of the mouse knockout model that shows excessive grooming behaviours that are alleviated with fluoxetine. In this study, we tested the SLITRK5 gene as a candidate for TS in a family-based sample with 377 affected children. Using single nucleotide polymorphisms tagging the gene, we did not find any evidence supporting the association of TS and SLITRK5.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Child
  • Family Health
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Mice
  • Nerve Tissue Proteins / genetics*
  • Obsessive-Compulsive Disorder / genetics*
  • Polymorphism, Single Nucleotide
  • Tourette Syndrome / genetics*
  • Whites / genetics

Substances

  • Membrane Proteins
  • Nerve Tissue Proteins
  • Slitrk5 protein, mouse