Omega-3 Fatty Acids and Primary and Secondary Prevention of Cardiovascular Disease

Cell Biochem Biophys. 2015 May;72(1):77-81. doi: 10.1007/s12013-014-0407-5.


The prevalence of cardiovascular disease (CVD) is increasing dramatically especially in developing countries like India. CVD is a leading cause of morbidity and mortality. There has been a growing awareness of the role of nutrients in the prevention of CVD. One specific recommendation in the battle against CVD is the increased intake of omega-3 fatty acids, which are polyunsaturated fatty acids. Studies have reported inverse associations of CVD with dietary intake of omega-3 fatty acids, suggesting that omega-3 fatty acids supplementation might exert protective effects on CVD. They exert their cardioprotective effect through multiple mechanisms. Omega-3 fatty acid therapy has shown promise as a useful tool in the primary and secondary prevention of CVD. This review briefly summarizes the effects of omega-3 fatty acids in primary and secondary prevention of CVD.

Keywords: Cardiovascular disease; Omega-3 fatty acids; Polyunsaturated fatty acids.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Arrhythmias, Cardiac / blood
  • Arrhythmias, Cardiac / prevention & control
  • Atrial Fibrillation / blood
  • Atrial Fibrillation / prevention & control
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / prevention & control*
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / prevention & control
  • Dietary Supplements*
  • Fatty Acids, Omega-3 / therapeutic use*
  • Female
  • Humans
  • Hypertension / blood
  • Hypertension / prevention & control
  • Male
  • Middle Aged
  • Primary Prevention / methods
  • Secondary Prevention / methods


  • Fatty Acids, Omega-3