Allergic reactions after egg-free recombinant influenza vaccine: reports to the US Vaccine Adverse Event Reporting System

Clin Infect Dis. 2015 Mar 1;60(5):777-80. doi: 10.1093/cid/ciu948. Epub 2014 Nov 26.


The Vaccine Adverse Event Reporting System has received reports of allergic reactions following immunization with egg-free recombinant influenza vaccine, among patients with a self-reported egg allergy or previous allergic reaction to inactivated influenza vaccine. These results suggest that allergic reactions following influenza vaccination are not necessarily related to egg proteins.

Keywords: allergy; egg; hypersensitivity; influenza; vaccine.

MeSH terms

  • Adolescent
  • Adult
  • Humans
  • Hypersensitivity / epidemiology*
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / adverse effects*
  • Middle Aged
  • United States / epidemiology
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / adverse effects
  • Young Adult


  • Influenza Vaccines
  • Vaccines, Synthetic