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. 2014 Nov 27;515(7528):496-8.
doi: 10.1038/515496a.

Cancer: Antitumour immunity gets a boost

Jedd D Wolchok  1 , Timothy A Chan  2
Affiliations

Cancer: Antitumour immunity gets a boost

Jedd D Wolchok et al. Nature. .
No abstract available

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Figures

Figure 1 |
Figure 1 |. Checkpoint blockade activates antitumour immunity.
a, Tumour cells express both cancer-driving mutations and ‘passenger’ mutations that cause the expression of neoantigens — ‘new’ molecular structures that, when presented by MHC proteins on the cell surface, are recognized by T cells of the immune system as being foreign, leading to an immune response against the tumour. However, interactions between the receptor PD-1 and its ligand PD-L1, which are expressed on tumour cells, T cells and other immune cells such as macrophages, activate signalling pathways that inhibit T-cell activity and thus inhibit the antitumour immune response. b, Antibodies that block the PD-1 pathway by binding to PD-1 or PD-L1 can reactivate T-cell activity and proliferation, leading to enhanced antitumour immunity.
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