Treatment of 308-nm excimer laser on vitiligo: A systemic review of randomized controlled trials

J Dermatolog Treat. 2015;26(4):347-53. doi: 10.3109/09546634.2014.991268. Epub 2015 Jan 30.


Background: Vitiligo is an acquired cutaneous hypopigmentary disorder, which characterized by solitary or multiple depigmented maculae or patches. The 308-nm excimer laser has been used as phototherapy on vitiligo.

Objective: To evaluate the efficacy and safety of 308-nm excimer laser on vitiligo.

Methods: Randomized controlled trials were searched to conduct a systematic review. The keywords were identified as laser/excimer laser/quasimolecule/XeCl" and "vitiligo".

Results: Seven studies with 390 vitiligo patients were included. No significant differences were seen between 308-nm excimer laser and 308-nm excimer lamp on either ≥75% or ≥50% re-pigmentation rate, or between 308-nm excimer laser and narrowband-ultraviolet B (NB-UVB) on either 100% or ≥75% re-pigmentation rate. More patients or lesions achieved ≥50% re-pigmentation rate by 308-nm excimer laser treatment than by NB-UVB treatment. The side effects of 308-nm excimer laser were slight and tolerable.

Conclusions: The 308-nm excimer laser showed equivalent efficacies to 308-nm excimer lamp control and NB-UVB control concerning ≥75% re-pigmentation rate of vitiligo patches. More studies with high methodological quality, low risk of bias and more sample size are needed to confirm the conclusion.

Keywords: 308-nm excimer laser; randomized controlled trials; systemic review; vitiligo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Humans
  • Lasers, Excimer / therapeutic use*
  • Phototherapy / methods*
  • Randomized Controlled Trials as Topic
  • Skin Pigmentation
  • Vitiligo / therapy*