The beneficial effects of ibuprofen on a lethal live E. coli septic shock model and the relationship of these effects to superoxide radical production

Prog Clin Biol Res. 1989:299:53-61.

Authors

D J Schmeling¹, R A Drongowski, A G Coran

Affiliation

¹ Department of Surgery, Mott Children's Hospital, University of Michigan, Ann Arbor 48109-0245.

PMID: 2542991

No abstract available

Publication types

Comparative Study

MeSH terms

Animals
Dogs
Dopamine / therapeutic use
Escherichia coli Infections / complications
Fluid Therapy
Free Radicals
Hemodynamics / drug effects
Ibuprofen / pharmacology
Ibuprofen / therapeutic use*
Lipid Peroxidation / drug effects
Nitriles
Oxamic Acid / analogs & derivatives
Oxamic Acid / pharmacology
Oxamic Acid / therapeutic use
Sepsis / complications
Shock, Septic / drug therapy*
Shock, Septic / etiology
Shock, Septic / physiopathology
Superoxides / biosynthesis*
Tromethamine / analogs & derivatives
Tromethamine / pharmacology
Tromethamine / therapeutic use
Xanthine Oxidase / antagonists & inhibitors

Substances

Free Radicals
Nitriles
Tromethamine
Superoxides
lodoxamide tromethamine
Xanthine Oxidase
Oxamic Acid
Dopamine
Ibuprofen