Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis

D A Zhebrun; Areg A Totolyan; A L Maslyanskii; A G Titov; A P Patrukhin; A A Kostareva; I S Gol'tseva

doi:10.1007/s10517-014-2720-9

Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis

Bull Exp Biol Med. 2014 Dec;158(2):192-6. doi: 10.1007/s10517-014-2720-9. Epub 2014 Nov 29.

Authors

D A Zhebrun¹, Areg A Totolyan, A L Maslyanskii, A G Titov, A P Patrukhin, A A Kostareva, I S Gol'tseva

Affiliation

¹ Pasteur Saint-Petersburg Research Institute of Epidemiology and Microbiology, St. Petersburg, Russia, zhebrun@almazovcentre.ru.

PMID: 25430645
DOI: 10.1007/s10517-014-2720-9

Abstract

We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Arthritis, Rheumatoid / metabolism*
Chemokines, CC / biosynthesis*
Chemokines, CC / metabolism
Female
Humans
Male
Middle Aged
Nephelometry and Turbidimetry
Osteoarthritis / metabolism*
RNA, Messenger / metabolism*
Receptors, CCR / biosynthesis*
Receptors, CCR / metabolism
Statistics, Nonparametric
Synovial Membrane / metabolism*

Substances

Chemokines, CC
RNA, Messenger
Receptors, CCR