Long Non-Coding RNAs Involved in Immune Responses

Front Immunol. 2014 Nov 13;5:573. doi: 10.3389/fimmu.2014.00573. eCollection 2014.


A large number of human RNA transcripts, which do not encode proteins are defined as non-coding RNAs (ncRNAs). These ncRNAs are divided into two classes of different lengths; short and long ncRNAs. MicroRNAs are a major class of short ncRNAs, ~22 nucleotides in length that regulate gene expression at the post-transcriptional level. Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and play roles in various biological pathways. In this review, we summarize the functions of lncRNAs which regulate immune responses.

Keywords: NEAT1; innate immune response; long non-coding RNA (lncRNA); translational repression.

Publication types

  • Review