Antimetastatic and anti-inflammatory potentials of essential oil from edible Ocimum sanctum leaves

ScientificWorldJournal. 2014;2014:239508. doi: 10.1155/2014/239508. Epub 2014 Nov 5.

Abstract

Antimetastatic and anti-inflammatory activities of Ocimum sanctum essential oil (OSEO) have been assessed in this study. OSEO at the concentration of 250 μg/mL and above showed a significant ((*) P < 0.05) decrease in the number of migrated cancer cells. In addition, OSEO at concentration of 250 μg/mL and above suppressed MMP-9 activity in lipopolysaccharide (LPS) induced inflammatory cells. A dose-dependent downregulation of MMP-9 expression was observed with the treatment of OSEO compared to the control. Our findings indicate that OSEO has both antimetastatic and anti-inflammatory potentials, advocating further investigation for clinical applications in the treatment of inflammation associated cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Cell Movement / physiology
  • Humans
  • Matrix Metalloproteinase 9 / metabolism
  • Ocimum*
  • Oils, Volatile / isolation & purification
  • Oils, Volatile / pharmacology*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Leaves*

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Oils, Volatile
  • Plant Extracts
  • Matrix Metalloproteinase 9