eNOS and coronary artery disease: publication bias and the eclipse of hypothesis-driven meta-analysis in genetic association studies

Gene. 2015 Feb 10;556(2):257-8. doi: 10.1016/j.gene.2014.11.052. Epub 2014 Nov 27.


Genome-wide association studies have eclipsed candidate gene association studies in genetic epidemiology in providing robust, unbiased evidence for the role of genetic variants in complex traits and diseases. The hypothesis-free nature of GWAS inherently minimises the risk of publication bias, and where available these studies should be considered in any meta-analysis of genetic association studies.

Keywords: Funnel plot; GWAS; Genetic association; Meta-analysis; Systematic review; eNOS.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Coronary Artery Disease / genetics*
  • Humans
  • Nitric Oxide Synthase Type III / genetics*
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic*


  • Nitric Oxide Synthase Type III