Mn(II) complexes of scorpiand-like ligands. A model for the MnSOD active centre with high in vitro and in vivo activity

J Inorg Biochem. 2015 Feb:143:1-8. doi: 10.1016/j.jinorgbio.2014.11.001. Epub 2014 Nov 15.


Manganese complexes of polyamines consisting of an aza-pyridinophane macrocyclic core functionalised with side chains containing quinoline or pyridine units have been characterised by a variety of solution techniques and single crystal x-ray diffraction. Some of these compounds have proved to display interesting antioxidant capabilities in vitro and in vivo in prokaryotic (bacteria) and eukaryotic (yeast and fish embryo) organisms. In particular, the Mn complex of the ligand containing a 4-quinoline group in its side arm which, as it happens in the MnSOD enzymes, has a water molecule coordinated to the metal ion that shows the lowest toxicity and highest functional efficiency both in vitro and in vivo.

Keywords: Antioxidant activity; Bacteria; Fish embryo models; Mn(II) complexes; Polyazamacrocyclic scorpiands; Yeast.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants* / chemical synthesis
  • Antioxidants* / chemistry
  • Catalytic Domain
  • Escherichia coli / enzymology
  • Escherichia coli Proteins / chemistry
  • Fish Proteins / chemistry
  • Ligands
  • Manganese / chemistry*
  • Models, Chemical*
  • Oryzias
  • Quinolines* / chemical synthesis
  • Quinolines* / chemistry
  • Saccharomyces cerevisiae / enzymology
  • Saccharomyces cerevisiae Proteins / chemistry
  • Superoxide Dismutase / chemistry*


  • Antioxidants
  • Escherichia coli Proteins
  • Fish Proteins
  • Ligands
  • Quinolines
  • Saccharomyces cerevisiae Proteins
  • Manganese
  • Superoxide Dismutase