Establishing a clinical and molecular diagnosis for hereditary colorectal cancer syndromes: Present tense, future perfect?

Gastrointest Endosc. 2014 Dec;80(6):1145-55. doi: 10.1016/j.gie.2014.07.049.

Authors

Marnix Jansen¹, Fred H Menko², Lodewijk A A Brosens³, Francis M Giardiello⁴, G Johan Offerhaus⁵

Affiliations

¹ Barts Cancer Institute, John Vane Science Centre, London, United Kingdom.
² Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
³ Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland, USA; Department of Pathology, University Medical Centre Utrecht, Utrecht, the Netherlands.
⁴ Department of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, USA.
⁵ Department of Pathology, University Medical Centre Utrecht, Utrecht, the Netherlands.

PMID: 25434663
DOI: 10.1016/j.gie.2014.07.049

No abstract available

Publication types

Review

MeSH terms

Adaptor Proteins, Signal Transducing / genetics
Adenomatous Polyposis Coli / diagnosis*
Adenomatous Polyposis Coli / genetics*
Adenomatous Polyposis Coli Protein / genetics
Adenosine Triphosphatases / genetics
Colorectal Neoplasms / diagnosis
Colorectal Neoplasms / genetics
Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis / genetics*
DNA Glycosylases / genetics
DNA Repair Enzymes / genetics
DNA-Binding Proteins / genetics
Disease Progression
Genetic Testing* / methods
Germ-Line Mutation
Humans
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1
MutS Homolog 2 Protein / genetics
Nuclear Proteins / genetics

Substances

APC protein, human
Adaptor Proteins, Signal Transducing
Adenomatous Polyposis Coli Protein
DNA-Binding Proteins
G-T mismatch-binding protein
MLH1 protein, human
Nuclear Proteins
DNA Glycosylases
mutY adenine glycosylase
Adenosine Triphosphatases
PMS2 protein, human
MSH2 protein, human
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1
MutS Homolog 2 Protein
DNA Repair Enzymes