miR-26a suppresses tumour proliferation and metastasis by targeting metadherin in triple negative breast cancer

Cancer Lett. 2015 Feb 1;357(1):384-392. doi: 10.1016/j.canlet.2014.11.050. Epub 2014 Nov 27.


It has been reported that miR-26a plays an important role in various cancers. In this study, we found that miR-26a was downregulated in triple-negative breast cancer (TNBC), and its expression levels were associated with lymph node metastasis and overall survival in TNBC. We also found that the ectopic expression of miR-26a inhibited TNBC cell proliferation and metastasis in vitro and in vivo by downregulating MTDH (a miR-26a' target gene) mRNA and protein and that the overexpression of MTDH could partially abrogate miR-26a-mediated suppression. Our data suggest that miR-26a functions as a tumour suppressor in TNBC development and serves as a prognostic marker for breast cancer.

Keywords: MTDH; Triple negative breast cancer; miR-26a.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Cell Adhesion Molecules / genetics*
  • Cell Adhesion Molecules / metabolism
  • Cell Growth Processes / genetics
  • Cell Line, Tumor
  • Female
  • Gene Expression Profiling
  • Humans
  • Membrane Proteins
  • Mice
  • Mice, Nude
  • MicroRNAs / administration & dosage*
  • MicroRNAs / biosynthesis*
  • MicroRNAs / genetics
  • Middle Aged
  • Neoplasm Metastasis
  • Prognosis
  • RNA-Binding Proteins
  • Tissue Array Analysis
  • Triple Negative Breast Neoplasms / genetics*
  • Triple Negative Breast Neoplasms / therapy*
  • Xenograft Model Antitumor Assays


  • Cell Adhesion Molecules
  • MIRN26A microRNA, human
  • MTDH protein, human
  • Membrane Proteins
  • MicroRNAs
  • RNA-Binding Proteins