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, 9 (1), 305-307

IL-32 Promotes Breast Cancer Cell Growth and Invasiveness

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IL-32 Promotes Breast Cancer Cell Growth and Invasiveness

Shouman Wang et al. Oncol Lett.

Abstract

Interleukin (IL)-32 is a newly identified cytokine in humans and primates. It has been established that IL-32 may antagonize cancer growth. However, to the best of our knowledge, the direct effect of IL-32 on breast cancer cell growth has not yet been investigated. In addition, rodents lack the expression of IL-32; hence, the effects of IL-32 on breast cancer xenografts in nude mice have not been studied. The present study aimed to examine the potential regulatory effects of IL-32 on breast cancer cells in nude mice. The effects of IL-32 on tumor cell growth in cell cuture and a tumor xenograft model were investigated, as well as the effects of IL-32 on apoptosis. The effects of IL-32 on cell proliferation and apoptosis were investigated by MTT assay and TUNEL staining, respectively. The results revealed that IL-32 increases the proliferation rate of cancer cells and decreases the rate of apoptosis, In addition, IL-32 was found to enhance the growth of tumor xenografts in vivo. In summary, IL-32 may represent a useful therapeutic target for human breast cancer.

Keywords: breast cancer; inflammation; interleukin-32.

Figures

Figure 1
Figure 1
Interleukin (IL)-32 enhances the growth of breast cancer cell xenografts in nude mice. *P<0.05 and **P<0.01, compared with the control group.

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