Recognition of preclinical and early disease in axial spondyloarthritis

Rheum Dis Clin North Am. 2014 Nov;40(4):685-97. doi: 10.1016/j.rdc.2014.07.011. Epub 2014 Aug 30.


In recent years the early identification of axial spondyloarthritis has become a high priority area of research. Evidence that therapy may slow radiographic progression of disease has heightened the importance of recognition of early disease. However, the concept of early axial spondyloarthritis and natural history of early disease are not fully understood. Future strategies to detect early and preclinical disease may incorporate clinical information, radiographic, serologic, and genetic testing. The risks and benefits of screening and early identification of disease need careful consideration.

Keywords: Ankylosing spondylitis; Diagnosis; Genetic testing; Magnetic resonance imaging; Serology.

Publication types

  • Review

MeSH terms

  • Back Pain / diagnosis*
  • Back Pain / etiology
  • Early Diagnosis
  • HLA-B27 Antigen / genetics
  • Humans
  • Inflammatory Bowel Diseases / complications
  • Magnetic Resonance Imaging
  • Psoriasis / complications
  • Spondylarthropathies / complications
  • Spondylarthropathies / diagnosis
  • Spondylarthropathies / genetics
  • Spondylitis, Ankylosing / complications
  • Spondylitis, Ankylosing / diagnosis*
  • Spondylitis, Ankylosing / genetics
  • Uveitis / complications


  • HLA-B27 Antigen