Antibody-dependent enhancement of yellow fever and Japanese encephalitis virus neurovirulence

J Gen Virol. 1989 Jun;70 ( Pt 6):1605-8. doi: 10.1099/0022-1317-70-6-1605.


Antibody-dependent enhancement of yellow fever virus neurovirulence, as measured by a reduction in the average survival time of groups of mice, was demonstrated with wild-type or vaccine strains of yellow fever virus and with Japanese encephalitis virus using intraperitoneally administered monoclonal antibodies specific for the viral E glycoprotein of yellow fever virus. Enhancement of virulence could be induced by neutralizing, non-neutralizing or protective antibodies if the virus was allowed to establish a productive infection in the mouse brain before the antibody was administered. The implications of antibody-dependent enhancement in flaviviruses are discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Viral / immunology*
  • Antibody Specificity
  • Brain Diseases / immunology
  • Brain Diseases / microbiology
  • Encephalitis Virus, Japanese / immunology
  • Encephalitis Virus, Japanese / pathogenicity*
  • Encephalitis, Japanese / immunology
  • Encephalitis, Japanese / microbiology
  • Mice
  • Neutralization Tests
  • Virulence
  • Yellow Fever / immunology
  • Yellow Fever / microbiology
  • Yellow fever virus / immunology
  • Yellow fever virus / pathogenicity*


  • Antibodies, Monoclonal
  • Antibodies, Viral