A novel reverse genetics system for human norovirus

Trends Microbiol. 2014 Nov;22(11):604-6. doi: 10.1016/j.tim.2014.10.001. Epub 2014 Oct 16.


Human noroviruses cause significant morbidity, mortality, and economic losses worldwide. The inability to grow human noroviruses in cell culture has hampered our collective understanding of virus-host interactions and development of therapeutics. A newly described single-plasmid reverse genetics system for noroviruses has the potential to facilitate basic and applied research.

Keywords: generation of reporter-tagged viruses; norovirus reverse genetics system.

MeSH terms

  • Animals
  • Cell Line
  • Genetic Vectors
  • Humans
  • Norovirus / genetics*
  • Norovirus / growth & development*
  • Plasmids
  • Reverse Genetics / methods*