Atrial fibrillation, stroke, and mortality rates after transcatheter aortic valve implantation

Am J Cardiol. 2014 Dec 15;114(12):1861-6. doi: 10.1016/j.amjcard.2014.09.025. Epub 2014 Sep 28.


Transcatheter aortic valve implantation (TAVI) is considered a suitable treatment for patients with severe symptomatic aortic stenosis and high operative risk. Our aim was to evaluate the effect of preprocedural and new-onset atrial fibrillation (NOAF) on mortality and stroke in patients who underwent TAVI. We performed a single-center study of 380 consecutive patients enrolled to a TAVI registry. NOAF was defined as postprocedural atrial fibrillation (AF) occurring within 30 days after the procedure. Patients were followed up for a mean of 528 ± 364 days. During follow-up, 19 (5%) new episodes of stroke occurred, of whom 6 and 18 cases occurred within 30 days and 1 year, respectively. Overall mortality during the follow-up was 68 (20%), of those 12 and 58 patients died within 30 days and 1 year, respectively. NOAF occurred in 31 (8.2%) patients and was not associated with higher stroke or mortality rates at 30 days or 1 year of follow-up. Notably, compared with patients without previous AF, patients with previous AF at baseline had increased rates of stroke and mortality at 1-year follow-up (2.1% vs 9.6%, p = 0.01, and 8.2% vs 34.9%, p <0.01; respectively). In multivariate analysis, AF at baseline but not NOAF was a significant predictor of mortality throughout the follow-up period (HR 2.2, 95% confidence interval 1.3 to 3.8, p = 0.003, and HR 1.5, 95% confidence interval 0.5 to 4.1, p = 0.390, respectively). In conclusion, previous AF at baseline but not NOAF significantly increases stroke and mortality rates after TAVI. The inclusion of AF into future TAVI risk stratification scores should be strongly considered.

MeSH terms

  • Aged, 80 and over
  • Aortic Valve Stenosis / surgery*
  • Atrial Fibrillation / epidemiology*
  • Atrial Fibrillation / etiology
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Israel / epidemiology
  • Male
  • Postoperative Complications
  • Prognosis
  • Registries*
  • Retrospective Studies
  • Risk Factors
  • Stroke / epidemiology*
  • Stroke / etiology
  • Survival Rate / trends
  • Transcatheter Aortic Valve Replacement / adverse effects*