The interrelationships of the gut microbiome and inflammation in colorectal carcinogenesis

Clin Lab Med. 2014 Dec;34(4):699-710. doi: 10.1016/j.cll.2014.08.002. Epub 2014 Sep 15.


The cause of colorectal cancer (CRC) is multifactorial, with genetic, molecular, inflammatory, and environmental risk factors. Recently, the gut microbiota has been recognized as a new environmental contributor to CRC in both animal models and human studies. An additional interplay of the gut microbiome with inflammation is also evident in studies that have shown that inflammation alone or the presence of bacteria/bacterial metabolites alone is not enough to promote tumorigenesis. Rather, complex interrelationships with the gut microbiome, inflammation, genetics, and other environmental factors are evident in progression of colorectal tumors.

Keywords: Carcinogenesis; Colorectal cancer; Gut microbiome; Inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Carcinogenesis*
  • Colon / microbiology*
  • Colon / pathology
  • Colorectal Neoplasms / microbiology*
  • Colorectal Neoplasms / prevention & control
  • Genetic Predisposition to Disease
  • Humans
  • Microbiota*
  • Probiotics / therapeutic use
  • Tumor Microenvironment