Structural parts involved in activation and inactivation of the sodium channel

Nature. 1989 Jun 22;339(6226):597-603. doi: 10.1038/339597a0.


Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • DNA
  • Mutation
  • Ovum
  • Plasmids
  • Sodium Channels*
  • Structure-Activity Relationship
  • Transfection
  • Xenopus


  • Sodium Channels
  • DNA