Management of extracranial carotid artery disease

Cardiol Clin. 2015 Feb;33(1):1-35. doi: 10.1016/j.ccl.2014.09.001.


Stroke is the third leading cause of death in developed nations. Up to 88% of strokes are ischemic in nature. Extracranial carotid artery atherosclerotic disease is the third leading cause of ischemic stroke in the general population and the second most common nontraumatic cause among adults younger than 45 years. This article provides comprehensive, evidence-based recommendations for the management of extracranial atherosclerotic disease, including imaging for screening and diagnosis, medical management, and interventional management.

Keywords: Antiplatelet therapy; Atherosclerotic disease; Carotid angioplasty and stenting; Carotid disease; Carotid endarterectomy; Carotid stenosis; Stroke.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Angiography
  • Angioplasty, Balloon
  • Carotid Stenosis / complications
  • Carotid Stenosis / diagnosis
  • Carotid Stenosis / therapy*
  • Cerebral Infarction / etiology
  • Cerebral Infarction / prevention & control
  • Endarterectomy, Carotid
  • Evidence-Based Medicine
  • Humans
  • Magnetic Resonance Angiography
  • Mass Screening
  • Platelet Aggregation Inhibitors / therapeutic use
  • Predictive Value of Tests
  • Stents
  • Tomography, X-Ray Computed
  • Ultrasonography


  • Platelet Aggregation Inhibitors