Anaphylaxis to succinylated gelatin in a patient with a meat allergy: galactose-α(1, 3)-galactose (α-gal) as antigenic determinant

J Clin Anesth. 2014 Nov;26(7):574-6. doi: 10.1016/j.jclinane.2014.04.014. Epub 2014 Oct 29.


Specific immunoglobulin E (sIgE) antibodies towards the galactose-α(1,3)-galactose (α-gal) moieties may elicit life-threatening and fatal anaphylactic reactions. Patients sensitized to α-gal moieties from mammalian meat may also react towards mammalian gelatins and gelatin-containing drugs such as bovine gelatin-based colloid plasma substitute. The case of a 56 year old woman with a meat allergy who suffered anaphylaxis to succinylated gelatin is reported.

Keywords: Gelatin allergy; Perioperative anaphylaxis; α-gal allergy.

Publication types

  • Case Reports

MeSH terms

  • Anaphylaxis / chemically induced*
  • Animals
  • Disaccharides / immunology*
  • Epitopes / immunology
  • Female
  • Food Hypersensitivity / complications*
  • Gelatin / adverse effects*
  • Humans
  • Immunoglobulin E / blood
  • Meat / adverse effects*
  • Middle Aged
  • Skin Tests
  • Succinates / adverse effects*


  • Disaccharides
  • Epitopes
  • Succinates
  • galactosyl-(1-3)galactose
  • Immunoglobulin E
  • succinylated gelatin
  • Gelatin