Anti-inflammatory effects of orally administered glucosamine oligomer in an experimental model of inflammatory bowel disease

Carbohydr Polym. 2015 Jan 22;115:448-56. doi: 10.1016/j.carbpol.2014.09.012. Epub 2014 Sep 21.

Abstract

Anti-inflammatory effects of oral administration of the glucosamine oligomers (chito-oligosaccharides: COS) were evaluated in an experimental model of inflammatory bowel disease (IBD). Oral administration of COS improved shortening of colon length and tissue injury (as assessed by histology) in mice. Oral administration of COS inhibited inflammation in the colonic mucosa by suppression of myeloperoxidase activation in inflammatory cells, as well as activation of nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase. Oral administration of COS also reduced serum levels of pro-inflammatory cytokines (tumor necrosis factor-α and interleukin-6). Moreover, it prolonged survival time in mice. These data suggest that COS have anti-inflammatory effects in an experimental model of IBD, and could be new functional foods for IBD patients.

Keywords: Anti-inflammatory; Functional food; Glucosamine oligomers; Inflammatory bowel disease; Nuclear factor-kappa B.

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents / administration & dosage*
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Body Weight / drug effects
  • Chitin / administration & dosage
  • Chitin / analogs & derivatives*
  • Chitin / pharmacology
  • Chitin / therapeutic use
  • Colon / drug effects
  • Colon / pathology
  • Cytokines / blood
  • Disease Models, Animal
  • Female
  • Inflammatory Bowel Diseases / blood
  • Inflammatory Bowel Diseases / drug therapy*
  • Inflammatory Bowel Diseases / metabolism
  • Inflammatory Bowel Diseases / pathology
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / pathology
  • Mice
  • Mice, Inbred C57BL
  • NF-kappa B / metabolism
  • Organ Size / drug effects
  • Survival Analysis

Substances

  • Anti-Inflammatory Agents
  • Cytokines
  • NF-kappa B
  • oligochitosan
  • Chitin