Mammalian-microbial cometabolism of L-carnitine in the context of atherosclerosis

Cell Metab. 2014 Nov 4;20(5):699-700. doi: 10.1016/j.cmet.2014.10.014. Epub 2014 Nov 4.

Abstract

γ-butyrobetaine has long been known as the precursor of endogenous L-carnitine synthesis. In this issue, Koeth et al. (2014) demonstrate that it is also a major metabolite of L-carnitine degradation by gut bacteria that precedes the enteric production of trimethylamine and trimethylamine-N-oxide.

Publication types

  • Comment

MeSH terms

  • Animals
  • Atherosclerosis / microbiology*
  • Betaine / analogs & derivatives*
  • Carnitine / metabolism*
  • Female
  • Gastrointestinal Tract / microbiology*
  • Methylamines / metabolism*

Substances

  • Methylamines
  • Betaine
  • Carnitine