Linking DNA damage, NAD(+)/SIRT1, and aging

Cell Metab. 2014 Nov 4;20(5):706-707. doi: 10.1016/j.cmet.2014.10.015. Epub 2014 Nov 4.

Abstract

Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of Cell Metabolism, Scheibye-Knudsen et al. (2014) demonstrate that increasing NAD(+) levels may reverse the inactivation of Sirt1 and mitochondrial defects in Cockayne Syndrome B that stem from nuclear NAD(+) depletion by the DNA repair protein PARP.

Publication types

  • Comment

MeSH terms

  • Aging, Premature / diet therapy*
  • Aging, Premature / etiology*
  • Animals
  • Cockayne Syndrome / complications*
  • Diet, High-Fat*
  • Humans
  • NAD / metabolism*
  • Sirtuin 1 / metabolism*

Substances

  • NAD
  • Sirtuin 1