Inflammation versus host defense in obesity

Huaizhu Wu; Christie M Ballantyne

doi:10.1016/j.cmet.2014.10.013

Inflammation versus host defense in obesity

Cell Metab. 2014 Nov 4;20(5):708-709. doi: 10.1016/j.cmet.2014.10.013. Epub 2014 Nov 4.

Authors

Huaizhu Wu¹, Christie M Ballantyne²

Affiliations

¹ Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: hwu@bcm.edu.
² Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital and Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Obesity is characterized by a state of low-grade, chronic inflammation. Wang et al. (2014) report that immune cells from obese mice have decreased production of IL-22, a cytokine involved in immune responses and inflammation, and reveal therapeutic effects of exogenous IL-22 against obesity-linked metabolic dysfunctions.

Publication types

Comment

MeSH terms

Animals
Diabetes Mellitus / immunology*
Diabetes Mellitus / metabolism*
Female
Immunity, Mucosal*
Interleukins / immunology*
Interleukins / metabolism*
Male
Metabolic Diseases / metabolism*

Substances

Interleukins

Grants and funding

R01 HL098839/HL/NHLBI NIH HHS/United States