Recent updates on incubation of drug craving: a mini-review

Addict Biol. 2015 Sep;20(5):872-6. doi: 10.1111/adb.12205. Epub 2014 Dec 1.


Cue-induced drug craving progressively increases after prolonged withdrawal from drug self-administration in laboratory animals, a behavioral phenomenon termed 'incubation of drug craving.' Studies over the years have revealed several important neural mechanisms contributing to incubation of drug craving. In this mini-review, we first discuss three excellent Addiction Biology publications on incubation of drug craving in both human and laboratory animals. We then review several key publications from the past year on behavioral and mechanistic findings related to incubation of drug craving.

Keywords: Addiction; cocaine; dopamine; glutamate; incubation; relapse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Behavior, Addictive / metabolism*
  • Behavior, Addictive / physiopathology*
  • Behavior, Addictive / psychology
  • Brain / metabolism
  • Brain / physiopathology
  • Craving / physiology*
  • Cues*
  • Disease Models, Animal
  • Dopamine / metabolism
  • Drug-Seeking Behavior / physiology
  • Glutamic Acid / metabolism
  • Humans
  • Recurrence
  • Reward
  • Substance-Related Disorders / metabolism*
  • Substance-Related Disorders / physiopathology*
  • Substance-Related Disorders / psychology


  • Glutamic Acid
  • Dopamine