Abstract
As enabling technology, the development and application of multicomponent reactions (MCRs) are now an integral part of the work of any major medical research unit. Targeted MCR approaches focused on specific antimitotic pathways afford new solutions for the medicinal chemistry of the XXI century. In this review, the contribution of these procedures to the discovery of antimitotic drugs that are currently in clinical trials or already in the market is discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antimitotic Agents / chemical synthesis*
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Antimitotic Agents / chemistry
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Antimitotic Agents / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Aurora Kinases / antagonists & inhibitors
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Aurora Kinases / metabolism
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Combinatorial Chemistry Techniques*
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Drug Discovery
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Humans
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Microtubules / chemistry
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Microtubules / drug effects
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Mitosis / drug effects*
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Molecular Docking Simulation
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Molecular Motor Proteins / antagonists & inhibitors
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Molecular Motor Proteins / metabolism
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Neoplasms / chemistry
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Neoplasms / drug therapy
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Neoplasms / pathology
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Protein Kinase Inhibitors / chemical synthesis*
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology
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Spindle Apparatus / chemistry
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Spindle Apparatus / drug effects
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Structure-Activity Relationship
Substances
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Antimitotic Agents
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Antineoplastic Agents
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Molecular Motor Proteins
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Protein Kinase Inhibitors
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Aurora Kinases